Fig. 5: The phenotypes of H19-ICRmSOC3/+ and H19-ICRmSOC4/+ mice. | Communications Biology

Fig. 5: The phenotypes of H19-ICRmSOC3/+ and H19-ICRmSOC4/+ mice.

From: Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith–Wiedemann syndrome-like overgrowth

Fig. 5

a Growth of H19-ICRmSOC3/+ (n = 10) and WT (n = 10), as well as (b) H19-ICRmSOC4/+ (n = 14) and WT (n = 10) neonates from 3 litters. Gray squares and red dots indicate individual weights of WT and heterozygous mutants with maternally transmitted H19-ICRmSOC3 or H19-ICRmSOC4 alleles, respectively. Horizontal and error bars indicate the mean ± SD, respectively. **; P < 0.01, *; P < 0.05 (two-tailed unpaired t-test). c Fetal weights in WT (n = 11) and H19-ICR mSOC3/+ (n = 13) mice from 3 litters at 15.5 dpc and WT (n = 4) and H19-ICR mSOC3/+ (n = 9) from 2 litters at 16.5 dpc. d Fetal weights in WT (n = 13) and H19-ICR mSOC4/+ (n = 6) mice from 3 litters at 15.5 dpc and WT (n = 9) and H19-ICR mSOC4/+ (n = 7) from 3 litters at 16.5 dpc. e Placental weights in WT (n = 11) and H19-ICR mSOC3/+ (n = 13) mice from 3 litters at 15.5 dpc and WT (n = 4) and H19-ICR mSOC3/+ (n = 9) from 2 litters at 16.5 dpc. f Placental weights in WT (n = 13) and H19-ICR mSOC4/+ (n = 6) mice from 3 litters at 15.5 dpc and WT (n = 9) and H19-ICR mSOC4/+ (n = 7) from 3 litters at 16.5 dpc. White and red dots indicate individual weights of WT and heterozygous mutants with maternally transmitted H19-ICRmSOC3 or H19-ICRmSOC4 alleles, respectively. Horizontal and error bars indicate the mean ± SD, respectively. P-values are indicated (unpaired two-tailed t-test). ns; not significant.

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