Fig. 6: AdipoRon stimulates the activity of voltage-gated channels in Tau neurons.
From: Reversal of neuronal tau pathology via adiponectin receptor activation
A Representative current responses of Tau and WT neurons following 24-treatment with 10 µM AR (or DMSO) in response to voltages of −40, −30, −20, −10, and 0 mV (darker to lighter shades). Stepwise voltage injections of 10 mV from 0–100 mV showing (B) maximum inward current, (C) maximum outward current, and (D) current–voltage curves. Repeated measures two-way ANOVA with Geisser–Greenhouse correction and post-hoc Tukey tests. Significant differences are shown as color-coded bars, mean ± SEM WT: 64 neurons, WT + AR: 13 neurons, Tau: 40 neurons, Tau+AR: 31 neurons.
