Fig. 4: Overlaps in DMR and miRNA expression between the fetal cortex and placenta. | Communications Biology

Fig. 4: Overlaps in DMR and miRNA expression between the fetal cortex and placenta.

From: Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations

Fig. 4: Overlaps in DMR and miRNA expression between the fetal cortex and placenta.

A miRNA overlap Venn diagram for transgenerational differentially expressed fetal cortex and placenta miRNAs. B miRNA overlap Venn diagram for multigenerational differentially expressed fetal cortex and placenta miRNAs. C Heat map shows log2 fold change for miRNA expression in the transgenerational and multigenerational models fetal cortex and placenta. D DMR overlap Venn diagram for transgenerational F3 generation fetal cortex and placenta differential DNA methylated regions. E DMR overlap Venn diagram for transgenerational F3 generation fetal cortex and placenta differential DNA methylated regions. F mRNA overlap Venn diagram for transgenerational differentially expressed fetal cortex and placenta genes. Pooled variance of the log2 fold change of overlapping genes is represented below. G mRNA overlap Venn diagram for multigenerational differentially expressed fetal cortex and placenta genes. Pooled variance of the log2 fold change of overlapping genes is represented below. H Heat map shows log2 fold change for mRNA expression for overlapping genes in the F3 transgenerational and multigenerational models for fetal cortex and placenta. Note that the grand majority of genes had similar patterns of expression.

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