Fig. 6: Maternal miRNA targets compared with fetal cortex and placenta differentially expressed genes. | Communications Biology

Fig. 6: Maternal miRNA targets compared with fetal cortex and placenta differentially expressed genes.

From: Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations

Fig. 6: Maternal miRNA targets compared with fetal cortex and placenta differentially expressed genes.

A Maternal F2 generation miRNAs were shown to be significantly altered in the prefrontal cortex and uterus from a previous study performed by this group8. B Maternal miRNA targets from the F2 generation uterus and cortex compared with F3 generation fetal cortex and placenta differentially expressed genes. C Maternal miRNA targets compared with F3 generation fetal cortex miRNA targets, DNAm, and mRNA. D Maternal miRNA targets compared with F3 generation fetal placenta miRNA targets, DNAm, and mRNA. Note that maternal miRNA targets showed similar or sometimes increased percentages of overlap with fetal DNAm and mRNA when compared to identified fetal miRNA targets.

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