Fig. 3: Genetic architecture of the circulating levels of the 40 cytokines. | Communications Biology

Fig. 3: Genetic architecture of the circulating levels of the 40 cytokines.

From: The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases

Fig. 3: Genetic architecture of the circulating levels of the 40 cytokines.

Circular Manhattan plot of genomic loci significantly associated with circulating levels of 40 cytokines in a meta-analysis of the three datasets. The 359 genome-wide significantly associated variants at p < 5 × 10−8 are depicted as black dots for GWAS meta-analyses in YFS & FINRISK, SCALLOP, and deCODE cohorts. The horizontal and vertical locations of dots in each single rectangle depict genomic positioning (increasing from left to right) and p-value (decreasing from bottom to top), respectively. SCALLOP Systematic and Combined AnaLysis of Olink Proteins, YFS & FINRISK Cardiovascular Risk in Young Finns Study.

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