Fig. 4: Trans- and cis-acting genetic variants underlying circulating cytokines. | Communications Biology

Fig. 4: Trans- and cis-acting genetic variants underlying circulating cytokines.

From: The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases

Fig. 4: Trans- and cis-acting genetic variants underlying circulating cytokines.

a Inverse correlation between minor allele frequency and effect size is illustrated for trans- and cis-acting loci, depicted as gray and red circles, respectively. b Number of significant loci binned by the number of associated circulating cytokines (excluding the HLA region on chromosome 6). c Cis-acting variants (n = 19, red bar) showed stronger associations with cytokine levels when compared with trans-acting variants (n = 150, gray bar). Bars and lines represent median and 95% confidence intervals, respectively. HLA human leukocyte antigen, SD standard deviation.

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