Fig. 7: Cross-cytokine genetic associations. | Communications Biology

Fig. 7: Cross-cytokine genetic associations.

From: The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases

Fig. 7: Cross-cytokine genetic associations.

a Genetic correlations (n = 1600) with LD-score regression across cytokine serum levels are depicted as a correlation heatmap. Stars highlight significance level *0.05; **0.0001; ***0.00001. LD-score correlation coefficients are illustrated according to the legend below spanning from −1 in blue to +1 in red, missing correlation coefficients are depicted in gray and are due to no evidence of SNP-heritability for one of the cytokines. b Cis-Mendelian randomization excluding variants associated with the exposure and outcome in the instruments lists between genetically proxied circulating cytokine levels (n = 65). Arrow heads show the direction of causal influence, color gradient indicates the effect estimate, and line width is the logarithm-adjusted Benjamin–Hochberg corrected significance level. LD linkage disequilibrium.

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