Fig. 5: Reorganization of the local lipid environments upon antigen binding to the BCR in the complex membrane.
From: Dynamics and activation of membrane-bound B cell receptor assembly
a All lipid molecules within 4Å distance of the membrane- peripheral region and membrane-bound helices of the BCR are considered. The numbers of surrounding lipid molecules during the last 100 ns of the AA (b) and CG MD simulations (c) in the complex membrane are shown. The bars for the BCR without and with antigen bound are colored blue and orange, respectively. The error bars represent the standard deviations. The p-values were calculated using the unpaired student’s t-test with the numbers of samples being the numbers of simulation replicas (N = 5) and shown on top of the bar graphs. The average numbers of surrounding lipid molecules for each simulation replica are included as red and green dots for the BCR without and with antigen bound, respectively.
