Fig. 1: Global genetic correlations among digestive diseases and psychiatric disorders.

a Heatmap of genetic correlation estimates between digestive diseases and psychiatric disorders. Positive genetic correlations are depicted in blue, while negative correlations are represented in red. Larger squares denote more significant FDR values, and asterisks indicate correlations that are statistically significant (FDR  <  0.05). ^∗FDR < 0.05, ^∗∗FDR < 0.01, ^∗∗∗FDR < 0.001. b Genetic correlation networks across digestive diseases and psychiatric disorders. Each circle within the network represents a disease or trait, and edges depict significant genetic correlations (FDR < 0.05), with positive correlations in blue and negative correlations in red. Thicker edges on the network correspond to a lower false discovery rate (FDR). IBS irritable bowel syndrome, GERD gastroesophageal reflux disease, PU peptic ulcer, AP acute pancreatitis, NAFLD non-alcoholic fatty liver disease, APP appendicitis, CRC colorectal cancer, IBD inflammatory bowel disease,CD Crohn’s disease, UC ulcerative colitis, SF stool frequency, DD diverticular disease, GD gastritis–duodenitis, ANX anxiety, NE neuroticism, MDD major depressive disorder, DEP depression, SCZ schizophrenia, ADHD attention-deficit hyperactivity disorder, BIP bipolar disorder, PTSD post-traumatic stress disorder.