Fig. 2: Local genetic correlations among digestive diseases and psychiatric disorders.

a Manhattan plot showing the estimates of local genetic correlation, genetic covariance, and SNP heritability between GERD and MDD in Europeans. b Manhattan plot showing the estimates of local genetic correlation, genetic covariance, and SNP heritability between GERD and DEP in Europeans. c Manhattan plot showing the estimates of local genetic correlation, genetic covariance, and SNP heritability between IBS and MDD in Europeans. Red bars represent loci showing significant local genetic correlation after multiple testing adjustment. GERD gastroesophageal reflux disease, IBS irritable bowel syndrome, MDD major depressive disorder, DEP depression.