Fig. 3: Estimates of tissue-specific contributions to 14 digestive diseases/traits by TCSC. | Communications Biology

Fig. 3: Estimates of tissue-specific contributions to 14 digestive diseases/traits by TCSC.

From: Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders

Fig. 3: Estimates of tissue-specific contributions to 14 digestive diseases/traits by TCSC.

TCSC estimates πt′, which denotes the proportion of disease heritability explained by the cis-genetic component of gene expression in tissue t′. a Analyses of all GTEx tissues. b Brain-specific analyses restricting to GTEx brain tissues. Asterisks denotes tissue-trait pairs with an P < 0.05, while red boxes denote tissue-trait pairs with a significant adjusted P (FDR <5%). Tissues are ordered alphabetically. IBS irritable bowel syndrome, GERD gastroesophageal reflux disease, PU peptic ulcer, AP acute pancreatitis, NAFLD non-alcoholic fatty liver disease, APP appendicitis, CRC colorectal cancer, IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis, SF stool frequency, DD diverticular disease, GD gastritis–duodenitis.

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