Fig. 6: Preservation of co-expression modules across brain and digestive tissues. | Communications Biology

Fig. 6: Preservation of co-expression modules across brain and digestive tissues.

From: Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders

Fig. 6

a Co-expression modules enriched in nervous system development and five closely correlated disorders (DEP, MDD, NE, IBS and GERD) are analyzed. Colors of the heatmap indicate module preservation, with Z values > 20 representing the strongest evidence, >10 denoting strong evidence, 2–10 suggesting weak to moderate preservation, and <2 indicating no preservation. Modules with labels colored in bule are further visulized in (b), while modules with labels colored in purple are visulized in (c). b The PPI network shows the shared genes from modules M2 [Amygdala], M17 [Esophagus Muscularis] and M13 [Colon Sigmoid] and c displays the shared genes from modules M4 [Cerebellum Hemisphere], M14 [Esophagus Gastroesophageal Junction], and M8 [Colon Sigmoid], with the size of the circles reflecting the gene’s rank in at least one of the three modules. The surrounding color shows if the gene is presented in each module.

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