Fig. 5: Dynamics of firing patterns during spatial memory acquisition.

a, d, g Upper panel: color-coded normalized time and z-scored firing rate for all neurons recorded in the mPFC (a) HPC (d), and PPC (g) aligned to behaviorally relevant events during non-spatial (upper) and spatial (lower) strategies. Lower panel: average z-scored peri-event time histogram during non-spatial (grey) and spatial strategies (purple). Shaded areas represent SEM. b, e, h Cumulative distribution of FSI for all neurons recorded in the mPFC (b) HPC (e) and PPC (h) during non-spatial and spatial strategies. c, f, i Box plot comparing the absolute value of the FSI between non-spatial and spatial strategies for all neurons recorded in the mPFC (c), HPC (f), and PPC (i). The middle, bottom, and top lines correspond to the median, lower, and upper quartiles, and the edges of the lower and upper whiskers correspond to the 5th and 95th percentiles. ***P < 0.001; Mann–Whitney test.