Fig. 8: A working model of USP35 regulating ferroptosis in ER+ breast cancer tumors.

USP35 interacts with and deubiquitinates BRD4, stabilizing the protein level of BRD4 that regulates SLC7A11. This interaction leads to USP35-invoked upregulating SLC7A11 expression, inhibiting ferroptosis, and promoting cell growth in ER+ breast cancer.