Fig. 2: Global knockout of Optn induces an osteoarthritis-like phenotype.
From: Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
a Representative images of Safranin O-fast green staining showing joint surface erosion in Optn-knockout (Optn−/−) mice. Representative images of immunohistochemical staining for analysis of the expression of collagen II (b), Aggrecan (c), MMP13 (d), and ADAMTS5 (e) in (Optn−/−) and wild-type mice (Optn+/+) mice. OARSI scores in the f medial femoral condyle (MFC) and g medial tibial plateau (MTP) of the Optn−/− and Optn+/+ mice. Quantification of immunohistochemical staining data: h collagen II, i aggrecan, j MMP13, and k ADAMTS5 in Optn−/− and Optn+/+ mice. Data are presented as the mean ± SEM (unpaired t-test, *p < 0.05, ***p < 0.001; n = 6).
