Fig. 1: The ESX-3 and ESX-4 secretion systems in M. abscessus.

a Schematic representation of the genetic organization of the esx-3 and esx-4 loci. The genes encoding the different ESX core components are shown using different colors. Genes encoding the secreted substrates are in gray. MAB_3755c (dark gray) encodes a protein with unknown function. b Model of the ESX-3/4 core components using the same color code than in (a). The ATPase domains of EccC3/EccC4 are indicated with triangles.