Fig. 8: Effect of formulated bambuterol on the protein level of synaptophysin and PSD95. | Communications Biology

Fig. 8: Effect of formulated bambuterol on the protein level of synaptophysin and PSD95.

From: Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route

Fig. 8

Effect of formulated bambuterol on the protein level of synaptophysin (pre-synaptic protein) (control = 0.023 ± 0.001 Synaptophysin/GAPDH) (A) and PSD95 (post-synaptic protein) (control = 0.021 ± 0.002 PSD95/GAPDH) (B) in brain samples of mice injected with vehicle (white), Aβ1-42 oligomers (red), and Aβ1-42 oligomers + bambuterol (300 µg/kg/day) (green). Results are expressed as mean ± SEM [(A): n = 6 except for bambuterol (n = 5), (B): n = 6 except for Aβ (n = 5)]. One-way ANOVA followed by Fisher’s LSD test. *p < 0.05 vs. Aβ1-42 was considered significant. Representative Western blots of rat primary hippocampal neurons after treatment with vehicle, Aβ1-42 oligomers, and Aβ1-42 oligomers + bambuterol (300 µg/kg/day) (C).

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