Fig. 1: PDE4DIP expression and prognostic analysis in lung cancer.
From: The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling
A Representative Western blot of PDE4DIP expression in NSCLC tissues. β-Actin was used as a control. N, adjacent tissues; T, tumour tissues. B Semiquantitative analysis of PDE4DIP protein levels in human NSCLC tumours. PDE4DIP protein expression in 60 paired NSCLC tumour tissues and adjacent tissues was assessed via Western blotting and quantified via Image J software. The optical density of the PDE4DIP band was quantified and normalized to that of the corresponding loading control, β-actin. C Kaplan–Meier survival analysis of patients with high vs. low PDE4DIP expression in lung tumour tissues in the GSE3141 cohort. The data were obtained using the R2 Genomics Analysis and Visualization Platform (http://r2.amc.nl). The optimal cut-off value for classification was determined by Kaplan–Meier scanning approach. D Kaplan–Meier disease-free survival analysis of patients with PDE4DIP-high vs. PDE4DIP-low NSCLC tumors obtained from Kaplan–Meier Plotter database (www.kmplot.com). The optimal cut-off value for classification was median.
