Fig. 3: RNA-seq analysis of male and female PCK rat kidney.
From: Electrolyte and metabolite composition of cystic fluid from a rat model of ARPKD
A Heatmap showing fold change differences for different animals. B Volcano plot of significantly up (orange) or down (blue) differentially expressed genes in females with a log2fold change (FC) > 1 and p-adjusted value < 0.05 as determined by differential expression analysis R-package DEseq2. C Signaling network demonstrating down-regulation of pathway-related genes including Vegf, Notch, Hif1a, and Cftr in females. Top Molecular and Cellular Functions (D), Gene Ontology Pathways (E), and KEGG Pathways (F) that are predicted to be different between male and female PCK kidney. N = 5 male and 5 female rats.
