Fig. 4: Differentially expressed ion channel genes expressed in the collecting duct.
From: Electrolyte and metabolite composition of cystic fluid from a rat model of ARPKD
Cftr and Tmem16A encode chloride channels: cystic fibrosis transmembrane regulator (CFTR) and the calcium-activated chloride channel Anoctamin. Aqp2 is the gene that transcribed aquaporin 2. Scnn1a, Scnn1b, and Scnn1g encode the α, β, and γ subunits of the epithelial Na+ channel (ENaC), respectively. Kcnj1, Kcnj10, and Kcnj16 encode the inward-rectifying K+ channels: ROMK, Kir4.1 and Kir5.1. Panx1, P2rx4, and P2rx7 transcribe an ATP-releasing channel (Pannexin1) and Ca+ transporting ionic purinergic receptors P2X4 and P2X7. Significance was determined by unpaired two-tailed t-test with p < 0.05 considered significant. Graphs demonstrate the mean ± SEM. *p < 0.05 **p < 0.01 ***p < 0.001. KPKM - Fragments Per Kilobase per Million mapped fragments. N = 5 male and 5 female rats.
