Fig. 6: Inflammation is linked to an impairment in the thermogenic program during the progression of T2D. | Communications Biology

Fig. 6: Inflammation is linked to an impairment in the thermogenic program during the progression of T2D.

From: Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue

Fig. 6

a Transcriptional network showing IRF1, IRF3, and IRF8 as regulators of the identified TFs targeting thermogenic genes. b-d IRF1, IRF3, and IRF8 relative expression, ANOVA with eBayes, significant difference vs. NW group *P < 0.05, **P < 0.01, ****P < 0.0001, significant difference vs. OW group #P < 0.05, ##P < 0.01. e Protein-protein interactome network depicting known proteins interacting with IRF1, IRF3, and IRF8. f Transcriptional network from interacting proteins illustrating the role of IRF1, IRF3, and IRF8 in their regulation. g Interactome DEGs per stage. h Significantly enriched pathways from the interactome. i Correlation heatmap between metabolism-related parameters (glucose, insulin, and HbA1c) and interactome genes per stage. Significant Spearman’s correlation coefficients (rho) were colored blue (positive) and red (negative), P < 0.01. NW (n = 7), OW (n = 8), PD (n = 7), T2D (n = 8), independent samples. Error bars as mean ± SEM.

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