Fig. 9: MiR-1 target genes in human lung and cancer field. | Communications Biology

Fig. 9: MiR-1 target genes in human lung and cancer field.

From: Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA

Fig. 9

A–D Human lung tissues were cultured ex-vivo and exposed to 1% CSE. mRNA/ reference gene levels were measured, normalized to the mean value of the control group(0), and expressed as 2−∆∆Ct. A NOTCH3 (n > 10,*p = 0.02) (B) HS3ST1 (n > 10, *p = 0.013) (C) SEMA4B (n > 10, *p = 0.0071) (D) TFAP4 (n > 10, *p = 0.024). E–H mRNA/ reference gene levels were measured in the tumor (T), adjacent tissue, (AT), and distant tissue (DT) samples from 12 smokers and expressed as 2−∆Ct. Analysis was done by applying the one-way ANOVA nonparametric Friedman test. E NOTCH3 (n = 12, p = 0.0001), (F) HS3ST1 (n = 12, p = 0.0005). G SEMA4B (n = 12, p = 0.0003), (H) TFAP4 (n = 12, p = 0.04).

Back to article page