Fig. 3: Differential expression of phosphoproteins and p53-pS15 and FOXO4 in fibroblasts from keloids and normal skins. | Communications Biology

Fig. 3: Differential expression of phosphoproteins and p53-pS15 and FOXO4 in fibroblasts from keloids and normal skins.

From: FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Fig. 3

Phosphoprotein expression profiles were detected using the CSP 100 plus phospho-specific protein microarray (Full Moon Microsystems). a Percentage of differentially expressed phosphoproteins in p53, apoptosis, and cell cycle signaling pathway. b The fold-change (FC) of differentially expressed phosphoproteins (FC ≥ 1.2 or FC ≤ 0.83) in cell cycle, p53, and apoptosis signaling pathway in keloid fibroblasts versus in normal adjacent skin fibroblasts. c Protein expression levels of p53-pS15 and FOXO4 in the nucleus and cytoplasm of keloid fibroblasts and normal skin fibroblasts detected using western blot analysis. (Nuc Nucleus, Cyto Cytoplasm) Data are shown as the means ± SD (n = 4; *p < 0.05).

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