Fig. 4: The expressions of p53-pS15 and FOXO4 in keloid and normal skin tissues. | Communications Biology

Fig. 4: The expressions of p53-pS15 and FOXO4 in keloid and normal skin tissues.

From: FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

Fig. 4

a Immunohistochemical staining and semi-quantitative analysis of normal skin and keloid sections for p53-pS15 and FOXO4 in brown and nuclear counterstaining in blue (scale bar = 500 μm). Black-boxed inserts show the expression of p53-pS15 and FOXO4 (black arrowheads) in fibroblasts of keloid dermis and normal skin dermis (scale bar = 100 μm). b Protein expression levels of p53-pS15 and FOXO4 in keloid and normal skin tissues detected using western blot analysis. N normal skin tissues, K keloid tissues. Data are shown as the means ± SD (n = 3; **p < 0.01, ***p < 0.001).

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