Fig. 6: Cartoon model of how Chol regulates EphA2 self-assembly and phosphorylation in the absence of ligand.
From: Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor
a Under normal membrane levels of Chol (yellow oval), the EphA2 assembly equilibria are such that monomer is the most abundant species. b When Chol content is reduced, Ser897 phosphorylation (red dot) is enhanced as oligomers are stabilized. For simplicity, the model does not show alternate conformation of the extracellular domain that is expected in a ligand-independent oligomer, as described in21.
