Fig. 10: A model on the role of PMCA4b in luminal epithelial cell polarization and lumen formation. | Communications Biology

Fig. 10: A model on the role of PMCA4b in luminal epithelial cell polarization and lumen formation.

From: The calcium pump PMCA4b promotes epithelial cell polarization and lumen formation

Fig. 10

PMCA4b facilitates the lumen forming capability of luminal epithelial cells through contributing to the polarized distribution of ezrin, and the plasma membrane localization of E-cadherin and Dlg1. During (pre-)lumen formation dynamic vesicular trafficking toward the emerging lumen area includes trafficking of PMCA4b through its Arf6-mediated recycling to the basolateral plasma membrane compartment. Losing PMCA4b, epithelial cells lose their polarized phenotype and acquire partial EMT characterized by cytoplasmic localization of E-cadherin, Dlg1 and ezrin.

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