Fig. 2: dnKASH expression reduces nuclear area.
From: Depletion of SUN1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis
a Representative photos of doxycycline induced DNKASH cells. Images show DNKASH tagged with mCherry (Red) and DNA (Blue). b mCherry intensity levels increased by 133% in doxycycline-treated MSCs (n = 5332, P < 0.0001). c Doxycycline-treated MSCs experienced a 14% decrease in the nuclear area (n = 5322, p 0.001). d Nuclear perimeter had a slight decrease of 1% in the doxycycline treatment group (n = 5322, P < 0.05). e Nuclear circularity decreased by 6% in the doxycycline treatment group (n = 5322, P < 0.0001). Comparisons were made against control using non-parametric Mann–Whitney test where *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. The scale bar represents 50 μm. The scale bar represents 50 μm. Results were presented as mean ± STD.
