Fig. 7: Correlation between gut microbiota, colon, PFC, PFC interneurons, and behaviors related to forced loss.
From: Perturbations in the microbiota-gut-brain axis shaped by social status loss
a Volcano plot displayed DEGs between the go-through-tube group and the forced-loss group in RNA-seq (Go-through-tube, n = 7; Forced loss, n = 7; ∣log2(FC)∣ > 0.585, and FDR < 0.05). b The biological processes related to the DEGs in RNA-seq were identified by GO enrichment analysis (p < 0.05). c KEGG pathway analysis of DEGs in RNA-seq (p < 0.05). d Heatmap showed the correlations between WGCNA modules from the gut microbiota, colon, PFC, PFC interneurons and behaviors related to the forced loss (r > 0.6 or < −0.6, *p < 0.05, **p < 0.01, ***p < 0.001, two-tailed Pearson correlation). The illustration was created in BioRender. Yang, R. (2025) https://BioRender.com/c35i595. e Co-expression network of KEGG pathways within WGCNA modules that were significantly associated with forced loss-related behaviors (r > 0.6 or < −0.6, and p < 0.05, two-tailed Pearson correlation).
