Fig. 3: Allosteric communication between the LBD and DBD of FXR-RXRα. | Communications Biology

Fig. 3: Allosteric communication between the LBD and DBD of FXR-RXRα.

From: Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex

Fig. 3: Allosteric communication between the LBD and DBD of FXR-RXRα.

A, B Schematic diagram of the HDX-MS experiment, left. Right, Comparison of A FXR-RXRα and FXR120(GW4064)-RXRα98(9cRA) as well as B FXR120(GW4064)-RXRα98(9cRA) and FXR120(GW4064)-RXRα98(9cRA)-hSHP-1, peptides with reduced or elevated deuterium uptake in HDX-MS were mapped to the FXR120-RXRα98 model (GW4064 in FXR and 9cRA in RXRα are shown in space-filling representation colored by atom type: oxygen as red, nitrogen as blue, sulfur as yellow, chlorine as green, and carbon as pink). Gray, no change in HDX between compared conditions; green to blue, slower rates of HDX between compared conditions; yellow to red, faster rates of HDX between compared conditions.

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