Fig. 5: Differential expression of MHC-II and related transcripts. | Communications Biology

Fig. 5: Differential expression of MHC-II and related transcripts.

From: Spatial transcriptomic profiling of the human fallopian tube epithelium reveals region-specific gene expression patterns

Fig. 5

a-d Boxplots of MHCII transcripts differentially expressed in the discovery cohort (n = 77 segments). a HLA-DRA, b HLA-DRB, c HLA-DPA1, d HLA-DQA1. e-h) Boxplots of MHCII transcripts differentially expressed in the validation cohort (n = 74 segments): e HLA-DRA, f HLA-DRB, g HLA-DPA1, h HLA-DQA1. All p-values are calculated using two-sided t-test. Green: fimbria; blue: infundibulum, red: ampulla, purple: isthmus; circles: pt_1, squares: pt_2, diamonds: pt_3, Lower and upper hinges of boxplot correspond to first (Q1) and third quartiles (Q3); central line corresponds to median. Whiskers of boxplot range from Q3 + 1.5 × IQR to Q1 - 1.5 × IQR. Scatterplots comparing i HLA-DRA, j HLA-DPA1, or k HLA-DQA1 expression to percentage of OVGP1 positive cells in equivalent IHC stained slides. Pearson’s correlation coefficient (R) and associated p-value are shown on scatterplots (calculated using the R package ‘ggpubr‘). Grey border around the line of best fit shows the 95% confidence interval.

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