Fig. 6: Schematic representation of cell-type distribution along the fallopian tube. | Communications Biology

Fig. 6: Schematic representation of cell-type distribution along the fallopian tube.

From: Spatial transcriptomic profiling of the human fallopian tube epithelium reveals region-specific gene expression patterns

Fig. 6

a Spatial transcriptomics profiling shows that the proportion of mature ciliated cells (green line) increases approaching the isthmus. CDH1 (E-cadherin) increases approaching the fimbria, while CDH3 (P-cadherin) expression increases approaching the isthmus. Created in BioRender. Sipes, J. (2025) https://BioRender.com/f36o257. b The fallopian tube undergoes a shift in peg cell (OVGP1 + ) distribution in timing with the ovulatory cycle. Pre-ovulation (follicular/proliferative phase), OVGP1 is upregulated, while MHC-II associated genes are suppressed, with the strongest effect in the central fallopian tube (infundibulum/ampulla). Post-ovulation (luteal/secretory), peg cells revert to normal secretory cells, and MHC-II genes return to a higher expression throughout the fallopian tube, with the isthmus showing the highest overall expression. MHC-II transcripts (blue, dotted line) show an increase approaching the isthmus. Dark green cell with cilia = mature ciliated cells; light green cell with cilia = immature/transitional ciliated cells. Created in BioRender. Sipes, J. (2025) https://BioRender.com/k86a54.

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