Fig. 3: Hypoxia treatment alters histone modifications of hMSMCs. | Communications Biology

Fig. 3: Hypoxia treatment alters histone modifications of hMSMCs.

From: HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility

Fig. 3

a Mean ChIP-seq density of histone modifications (H3K27ac, H3K4me1, H3K27me3, H3K4me3) at all genes’ bodies (transcription start sites, TSS; transcription end sites, TES). Red line represents the hypoxia group, blue line represents the control group. Significance was determined by by two-side Wilcoxon test. ****p < 0.0001; ns, p > 0.05. b Venn diagram illustrating the overlap in histone modification peaks (H3K27ac, H3K4me1, H3K27me3, H3K4me3) between hypoxia and control groups. c Heatmap showing the correlation between different histone modifications under hypoxia or control conditions.

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