Fig. 5: The HIF1A is enriched and specifically bind to the higher H3K27ac modifications regions in hMSMCs under hypoxia. | Communications Biology

Fig. 5: The HIF1A is enriched and specifically bind to the higher H3K27ac modifications regions in hMSMCs under hypoxia.

From: HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility

Fig. 5

a Predicted transcription factors (TFs) binding at the peaks with higher H3K27ac levels in the hypoxia group overlap with upregulated TFs during labor in both bulk and single-cell transcriptomics data. The lower right corner highlights HIF1A and shows its motif sequence. b Distribution of HIF1A peaks in promoters and enhancers in hypoxia hMSMCs. c Mean ChIP-seq density of histone modifications (H3K27ac, H3K4me1, H3K27me3, H3K4me3) in the hypoxia group at HIF1A ChIP-seq peaks.

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