Fig. 6: Inhibition of CD38 palmitoylation by peptides slows Pano2 pancreatic cancer growth.

A–D C57BL/6 mice were subcutaneously injected with Pano2 cells and treated with DMSO (Vehicle group), CPPtat-S1 Control peptide, or CPPtat-S1 peptide (10 mg/kg). A Schematic diagram showing the treatment plan. B–D Tumor volumes were measured every 2 days. Tumor size was weighed and photographed at the end of treatment. E After peptide treatment, a part of the tumor tissue was removed and paraffin embedded, and representative images of HE staining and IHC staining (Ki67, Tunel, CD38) were obtained. The scale is 50 μm. F, G The number of positive cells in Ki67 and Tunel under 40× mirror field was quantified by IHC staining. All results are presented as mean ± SEM. B–G Statistical analyses were calculated using a one-way ANOVA with a Tukey post hoc test (n = 5) (ns not significant, *p < 0.05, **p < 0.01, and ***p < 0.001).