Fig. 1: Illustration of the computational pipeline.
From: Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization
The BioID virus-host proximal interactomics datasets are combined and encoded into a weighted graph data structure. This structure is augmented with previously reported host-host interactions, and a multi-stage and force-directed graph layout is used to generate 3D coordinates of all nodes. The modeled 3D map can be accessed in a web-based interactive display, with option for with filtering and customization features. Further integration with other available interactomes from a variety of study types resulting in a global comparative interactome view.
