Fig. 2: SARS-CoV-2-human proximal network representation.
From: Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization
a Global data-driven SARS-CoV-2-human proximal network projection on 2D and its relaxation upon removal of the host proteins targeted by eight or more viral baits. PxIs stands for proximal interactions. b Spatial localization of functional groups of proteins in the proximal network relative to the viral proteins (black nodes), as indicated. c Localization of human proteins essential for SARS-CoV-2 induced toxicity (3 + CRISPR hits) on the SARS-CoV-2-host 2D proximal interaction map. d Picture of the global comparative view of the SARS-CoV-2-host interactomes, highlighted in blue, red and pink are the SARS-CoV-2-host interactions identified in two-hybrid, low throughput study and our BioID study, respectively. e Histograms and densities of viral-host protein pair distances in the global 3D SARS-CoV-2-host proximal interaction map and breakdown by their origin study type.
