Fig. 7: TMCO1 deficiency results in ER Ca2+ overload. | Communications Biology

Fig. 7: TMCO1 deficiency results in ER Ca2+ overload.

From: Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

Fig. 7: TMCO1 deficiency results in ER Ca2+ overload.

A The heatmap results of scRNA-seq showed the gene expression profile of Ca2+ channels on ER. The red rectangle labeled TMCO1 expression in each sample. B Representative flow cytometric graphs and (C) the cumulative statistical results showed the expression of TMCO1 in MAIT cells from HFRS patients in acute phase and normal controls (N = 4). Staining of the cells with isotype-matched control antibody (isotype) served as negative control. D Representative flow cytometric graphs and the cumulative statistical results showed ER Ca2+ stored in MAIT cells from both HFRS patients and NC (N = 15). *p < 0.05.

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