Fig. 3: Regional control energy and its temporal correlation with signal diversity and drug intensity are associated with serotonin 2a receptor maps.
a Regional control energy metrics. (left) The change in regional control energy in the 8 min after DMT injection, relative to the 8 min prior to the injection. (middle) Each region’s control energy time-series over the course of the full 28 min DMT scans correlated with global signal diversity from EEG during the same scans. (right) Regional control energy during the DMT scans was averaged over one-minute windows corresponding to the timing of subjective drug intensity ratings from separate scans. The windowed control energy time-series for each region was then correlated with the subjective drug intensity ratings. b Each of the regional metrics in (a) were then correlated with the cortical spatial map of the serotonin 2a receptor derived from PET39. The strength of these correlations were compared against null correlations with 10,000 cortical spin permutations40 of the 2a receptor map. c Scatter plots of the three cortical regions’ metrics (n = 100 regions) from (a) and serotonin 2a receptor density from (b).
