Fig. 4: Dominance analysis reveals the highest relative importance of the serotonin 2a receptor in DMT-related changes in cortical activity metrics. | Communications Biology

Fig. 4: Dominance analysis reveals the highest relative importance of the serotonin 2a receptor in DMT-related changes in cortical activity metrics.

From: Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

Fig. 4

Three separate dominance analyses were performed using cortical values from five PET-derived serotonin receptor and transporter spatial densities39 as input variables and each cortical metric from Fig. 3a as the output. Dominance analysis assesses the relative importance of each input in explaining the output variable’s variance while controlling for the contributions of other predictors in multiple regressions41. Displayed is the percent relative importance given to each receptor/transporter map for explaining the variance in each cortical metric, as determined by dominance analysis. n = 116 regions; 5-HT = serotonin (5-hydroxytryptamine).

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