Fig. 2: Characterization of COL/NIC-mPEG-PLGA-NPs. | Communications Biology

Fig. 2: Characterization of COL/NIC-mPEG-PLGA-NPs.

From: Amphiphilic mPEG-PLGA copolymer nanoparticles co-delivering colistin and niclosamide to treat colistin-resistant Gram-negative bacteria infections

Fig. 2

a Particle size and size distribution of COL/NIC-mPEG-PLGA-NPs. b Zeta potential characterization of COL/NIC-mPEG-PLGA-NPs. c Representative TEM image of COL/NIC-mPEG-PLGA-NPs. d FTIR spectra of colistin, niclosamide, mPEG-PLGA, COL/NIC-mPEG-PLGA-NPs. e Storage stability of COL/NIC-mPEG-PLGA-NPs at 4 °C. f–h Changes in the size (f), Zeta (g), and PDI (h) of COL/NIC-mPEG-PLGA-NPs stored in various media at 37 °C for 3 days. (PBS phosphate-buffered saline, FaSSGF fasted state simulated gastric fluid, FaSSIF fasted state simulated intestinal fluid, n = 3). i The colistin and niclosamide release profile of COL/NIC-mPEG-PLGA-NPs. The experiments were repeated three times independently, and representative data are displayed.

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