Fig. 1: Schematic of PROTAC activity.
From: Cellular parameters shaping pathways of targeted protein degradation
The heterobifunctional small molecule promotes ternary complex formation between E3 and a target protein (1) to bring about ubiquitination (2) then degradation (3) of the target as a ‘neo-substrate’ of the E3. Created in BioRender. Cardno, A. (2025) https://BioRender.com/7ggcsvs.
