Fig. 1: Hippocampal subfield volumes showed greater sensitivity to age compared to early stress.

A The relationship between subfield volumes (y-axis) and age (x-axis). B Segmentation of hippocampal subfield volumes was performed using an iterative approach, with a group-based neonatal template for initial registration before being labeled and unfolded. Colours represent the R² values for the age (top) and stress (bottom) models, showing the model fit across the hippocampus. Warm colours indicate higher R² values, while cooler colors show lower model fit. C Subfield volumes in preterm-born, term-equivalent preterm-born, and term-born infants. Medians are indicated by thick black horizontal lines. The first and third quartiles are marked by the lower and upper edges of the boxes, respectively. Lower and upper whiskers extend to the smallest and largest value, respectively, within 1.5 times the interquartile range. Outlying values beyond these ranges are plotted individually. CA cornu ammonis, DG dentate gyrus, TE term equivalent.