Fig. 3: QA-score for mutation correction.
From: Self-authenticating genomic materials in Escherichia coli via advanced genome signatures
a Diagram of the Comb-Hash Mapping process in GMS decoding illustrating the detection of a specific mutation (3,302,560 C > G). Substitution of 3,302,560 C > G causes changes in GMS. Comb-Hash mappings of both the origin nucleotide C related (error-out, green line) and the substitution G related (error-in, red line) are quantified as a value, termed as QA-score (questionable authenticity score). Non-changed Comb-Hash mappings are indicated with gray solid lines. b Quality Assurance (QA) score profile across the genomic sequence showing baseline values in the absence of mutations. c QA score profile revealing a significant spike at the mutation position of substitution 3,302,560 (C > G) within the genome sequence, the inset displays the 20 nucleotides surrounding mutation. d The mutated C > G 3,302,560 nucleotide scored 1. All other nucleotides scored ≤ 0.5, and over 99.99% of them scored below 0.3.
