Table 3 List of drugs tested in HepG2 spheroids or liver organoids
From: Development of an AI model for DILI-level prediction using liver organoid brightfield images
No. | Compounds | DILIrank | Severity class | Label section |
|---|---|---|---|---|
1 | Troglitazone | vMost-DILI-Concern | 8 | Withdrawn |
2 | Pioglitazone | vLess-DILI-Concern | 3 | Warnings and precautions |
3 | Tolcapone | vMost-DILI-Concern | 8 | Box warning (withdrawn) |
4 | Entacapone | vLess-DILI-Concern | 0 | No match |
5 | Nefazodone | vMost-DILI-Concern | 8 | Box warning |
6 | Buspirone | Ambiguous DILI-concern | 3 | Adverse reactions |
7 | Trovafloxacin | vMost-DILI-Concern | 8 | Withdrawn |
8 | Levofloxacin | vMost-DILI-Concern | 8 | Warnings and precautions |
9 | Cyclophosphamide | vLess-DILI-Concern | 5 | Adverse reactions |
10 | Methotrexate | vMost-DILI-Concern | 3 | Box warning |
11 | Paclitaxel | vLess-DILI-Concern | 4 | Adverse reactions |
12 | Erlotinib | vMost-DILI-Concern | 8 | Warnings and precautions |
13 | Gefitinib | vMost-DILI-Concern | 4 | Warnings and precautions |
14 | Dasatinib | vLess-DILI-Concern | 4 | Adverse reactions |
15 | Vinblastine | vNo-DILI-Concern | 0 | No match |
16 | Acetaminophen | vMost-DILI-Concern | 5 | Warnings and precautions |
17 | Benzbromarone | vMost-DILI-Concern | 8 | Withdrawn |
18 | Bosentan | vMost-DILI-Concern | 7 | Box warning |
19 | Diclofenac | vMost-DILI-Concern | 8 | Warnings and precautions |
20 | Flutamine | vMost-DILI-Concern | 8 | Box warning |
21 | Isoniazid | vMost-DILI-Concern | 8 | Box warning |
22 | Nimesulide | vMost-DILI-Concern | 8 | Withdrawn |
23 | Stavudine | vMost-DILI-Concern | 8 | Box warning |
24 | Simvastatin | vLess-DILI-Concern | 3 | Warnings and precautions |
25 | Zileuton | vMost-DILI-Concern | 5 | Warnings and precautions |
26 | Chlorpheniramine | vNo-DILI-Concern | 0 | No match |
27 | Digoxin | vNo-DILI-Concern | 0 | No match |
28 | Diphenhydramine | vNo-DILI-Concern | 0 | No match |
29 | Hydrocortisone | vNo-DILI-Concern | 0 | No match |
30 | Lidocaine | vNo-DILI-Concern | 0 | No match |
