Fig. 7: Proposed model for Ca2+ uptake via the DdMCU-DdMICU complex.
From: Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics
a Model of the DdMCU-DdMICU complex in low and high Ca2+ states. In the resting condition, DdMICU binds to the DdMCU pore and the membrane through conserved N-terminal residues and the C-helix. In the high Ca2+ state, DdMICU dissociates from the DdMCU, enabling Ca2+ uptake through the DdMCU. DdMICU remains anchored to the membrane via its C-helix. b Horizontal model of the DdMCU-DdMICU holo-complex. IMS, IMM, and Matrix indicate the intermembrane space, inner mitochondrial membrane, and mitochondrial matrix, respectively.
