Table 3 Dimer interface analysis of MICU structures
From: Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics
Dimer formation | H-H dimer | F-F dimer | B-B dimer | ||||||
|---|---|---|---|---|---|---|---|---|---|
Protein (PDB code) | DdMICU (9K6M) | DdMICU (9K6M) | HsMICU1 (4NSD) | HsMICU1-2 (6XQO) | HsMICU2 (6IIH) | HsMICU3 (6AGI) | HsMICU2 (6IIH) | HsMICU3 (6AGI) | |
Interface area (Å2) | 650 | 1370 | 470 | 1310 | 1260 | 1640 | 760 | 640 | |
Number of interfacial contacts (ICs) | charged-charged | 16 | 2 | 6 | 4 | 8 | 8 | 9 | 6 |
charged-polar | 15 | 6 | 4 | 9 | 7 | 9 | 8 | 6 | |
charged-apolar | 11 | 20 | 9 | 15 | 15 | 26 | 23 | 10 | |
polar-polar | 2 | 0 | 1 | 4 | 3 | 4 | 2 | 4 | |
polar-apolar | 8 | 16 | 4 | 17 | 7 | 10 | 2 | 7 | |
apolar-apolar | 2 | 48 | 4 | 32 | 39 | 54 | 13 | 12 | |
∆G (kcal/mol) | −8.7 | −10.6 | −6.6 | −9.6 | −8.2 | −9.3 | −8.0 | −6.9 | |
Kd (M) | 4.2 ×10−7 | 1.7 ×10−8 | 1.4 ×10−7 | 9.7 ×10−8 | 9.8 ×10−7 | 1.5 ×10−7 | 1.4 ×10−6 | 9.3 ×10−6 | |
