Fig. 3: Comparison of neutralizing antibodies targeting the E2 front layer. | Communications Biology

Fig. 3: Comparison of neutralizing antibodies targeting the E2 front layer.

From: Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers

Fig. 3

a Surface representations of HC84.26.5D–E2, AR3X–E2 (PDB code 6URH), HEPC3–E2 (6MEI), 1382_01_H05–E2 (7RFC), and RM2-01–E2 (7JTF) complexes20,23,24,26. All structures are superposed on E2 of the HC84.26.5D–E2 complex to illustrate differences in the angle of approach of VH1-69 neutralizing antibodies with respect to E2. The Fab constant domains are not shown for clarity. E2 surfaces are colored by structural components: hypervariable regions, yellow; front layer, cyan; β-sandwich, orange; CD81 binding loop, blue; post-VR3, gray; AS412 region, pink; back layer, green. H and L chains are shown in dark gray and white, respectively. b Epitopes of the front layer-specific neutralizing antibodies are colored on the E2 surface based on their structural components, with interacting residues labeled. Footprints for H chain CDRs are displayed separately.

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