Fig. 8: Transcriptional differences between HG and LG CRC cell lines grown in vitro are retained in xenografts, PDTOs and primary CRCs. | Communications Biology

Fig. 8: Transcriptional differences between HG and LG CRC cell lines grown in vitro are retained in xenografts, PDTOs and primary CRCs.

From: Model systems and unique biological features of high and low-grade colorectal cancer (CRC) revealed by xenografting 84 human CRC cell lines

Fig. 8: Transcriptional differences between HG and LG CRC cell lines grown in vitro are retained in xenografts, PDTOs and primary CRCs.

A–C Pearson correlations of the magnitude of differential expression of genes between HG and LG cell lines (logFC) with the corresponding change in expression between HG versus LG A xenografts, B PDTOs and C TCGA cases. D, E Canberra clustering of D n = 95 LG and n = 9 HG transcriptionally profiled patient-derived tumour organoids39, and E n = 202 LG and n = 58 HG primary CRCs profiled by the TCGA, based on a 90 gene signature derived from the 1763 DEGs in cell lines using an elastic net approach.

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