Fig. 1: Single-cell and bulk multi-omics profiling of bone marrow samples from AML patients at diagnosis. | Communications Biology

Fig. 1: Single-cell and bulk multi-omics profiling of bone marrow samples from AML patients at diagnosis.

From: Discovery of candidate functional non-coding mutations in acute myeloid leukemia using single-cell chromatin accessibility sequencing

Fig. 1

a Overview of study design, sample collection, single-cell profiling, and analyses. b UMAP visualization for scATAC-seq across samples (left) and major hematopoietic cell types (right). c scATAC-seq gene activity scores for the representative marker genes across scATAC-seq clusters. Color indicates relative gene activity across all clusters, and dot size indicates the percentage of cells showing gene activity in each cluster. d Fraction of cells in each scATAC-seq cluster across samples. e Genome tracks of the accessibility near the marker genes. f UMAP for the representative motif activity score identified by ChromVAR across major hematopoietic cell types.

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