Fig. 6: Inhibition of Oxytocin Receptors in the PAG Disrupts SRM in Mice. | Communications Biology

Fig. 6: Inhibition of Oxytocin Receptors in the PAG Disrupts SRM in Mice.

From: Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity

Fig. 6

A Administration paradigm of oxytocin receptor inhibitors, with a microinjection of the drug into the vlPAG 30 min before the five-trial experiment. B Statistical analysis of interaction times between C57 mice with microinjections of Atosiban or L-371,257 in the PAG and same strain stimulus mice. C57 mice administered Atosiban (n = 8) or L-371,257 (n = 7) showed disrupted SRM for same strain mice. Administration of saline (n = 6) did not affect the SRM of C57 mice. C C57 mice administered Atosiban (n = 7) or L-371,257 (n = 8) showed disrupted SRM for other strain mice. Administration of saline (n = 6) did not affect the SRM of C57 mice. D Administration paradigm of oxytocin receptor inhibitors, with a microinjection of the drug into the vlPAG 30 min before the stimulus mouse was changed in the fifth trial of the five-trial experiment. E C57 mice administered Atosiban (n = 6) or L-371,257 (n = 6) before the fifth trial showed disrupted individualized SRM for same strain mice. Administration of saline (n = 6) did not affect the SRM of C57 mice. Data displayed as mean±S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001. T1: Trial 1, T4: Trial 4, T5: Trial 5.

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